Monthly Archives: April 2016

  1. Demystifying NGS Outsourcing: Aligning Resources, Expertise, and Needs

    Overview:

    The goal of the modern genomics researcher is not simply to build genomics tools or even to gather genomic data. Instead, the ultimate objective is to further scientific knowledge – to better understand human disease, plant and animal genetics, microbial ecology or evolution. The genomics researcher or bioinformatician seeks a deeper understanding of the science; better research tools are only a means to this end. A number of complex steps are involved in genomic sequencing, including platform or vendor selection, sample preparation, sequencing, data management and bioinformatics. Each of these individual processes bears its own learning curve, and a failure at any step could cripple downstream results. Next Generation Sequencing (NGS) innovations have lowered a number of barriers that once stood between the researcher and the creation of new genomic knowledge. Because of these br

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  2. Next Generation Sequencing - Overview and Solutions to Common Problems

    Background:

    Current Next-Generation Sequencing (NGS) platforms employ massively parallel, automatable sequencing approaches designed for maximum output and efficiency. With vastly improved speed and efficiency, modern NGS platforms have enabled an entirely new paradigm for genomic research, with new applications in human disease, small-genome species, metagenomics, consumer testing and more. Early NGS innovations (e.g., Roche/454, SOLiD) have been outpaced by the more recent platforms of Illumina, PacBio and Ion Torrent. Because of the different chemistries and detecti

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