Metagenomics is a very broad field that can often be summarized down to the analysis of a microbiome. These microbiomes are all around and inside us. They’re in the air we breathe, the water we drink and the food we eat.
The genome is the unique blueprint of every living organism on earth. In almost every other species like humans, exhaustive research has demonstrated it is also in concert with environmental and epigenetic factors. Changes in it, is undeniably one of the pillars of disease pathogenesis - or lack thereof.
For many projects, it can be overkill to do Whole Genome Sequencing (WGS). Projects with a more specific focus can leverage Whole Exome Sequencing (WES), thanks to its higher coverage and lower overall cost.