Hi-C

High Throughput Chromosome Conformation Capture (Hi-C)

Hi-C assay is an extension of chromosome conformation capture (3C) assay studying chromosomal interactions. While 3C and its subsequent adaptations require the choice of a set of target loci, Hi-C employs high-throughput sequencing and can identify genome-wide unbiased long-range interactions. Hi-C results reveal chromosomal interactions such as compartmentations, topologically associating domains (TADs) and chromatin loops.

Applications
Intra/Interchromosomal interaction
Promoter-Enhancer interaction
DNA folding status

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