High Throughput Chromosome Conformation Capture (Hi-C)
Hi-C assay is an extension of chromosome conformation capture (3C) assay studying chromosomal interactions. While 3C and its subsequent adaptations require the choice of a set of target loci, Hi-C employs high-throughput sequencing and can identify genome-wide unbiased long-range interactions. Hi-C results reveal chromosomal interactions such as compartmentations, topologically associating domains (TADs) and chromatin loops.
DNA folding status