Whole Genome Bisulfite Sequencing

Whole Genome Bisulfite Sequencing (WGBS)

Naturally-occurring methylation of DNA at the cytosine residues is an important component in many studies including that of epigenetic studies. With this occurrence in mind, converting and studying these sites is referred to as whole genome bisulfite sequencing (WGBS). This technology is a genome-wide profiling of DNA methylation sites. WGBS is a comprehensive cytosine modification profiling method which provides insight into topics relating to epigenomic mapping, patterns of epigenetic marks, aberrant methylation characterized by cancers, and much more.

Applications
Coding Variant Detection (germline, somatic)
Mutation discovery
Disease-related variant discovery

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