Whole Genome Bisulfite Sequencing (WGBS)
Naturally-occurring methylation of DNA at the cytosine residues is an important component in many studies including that of epigenetic studies. With this occurrence in mind, converting and studying these sites is referred to as whole genome bisulfite sequencing (WGBS). This technology is a genome-wide profiling of DNA methylation sites. WGBS is a comprehensive cytosine modification profiling method which provides insight into topics relating to epigenomic mapping, patterns of epigenetic marks, aberrant methylation characterized by cancers, and much more.
Coding Variant Detection (germline, somatic)
Disease-related variant discovery